SPANISH LANGUAGE

DURATION: 12 hours

MODALITY: LIVE (12PM) and ASYNCHRONOUS (12PM) - ONLINE -

Brief Review: In this course you will learn about Polycystic Ovary Syndrome, differential diagnosis, exclusion criteria, contraceptives and their effects, nutritional treatment and much more, to be able to properly treat this type of patient.

Complete agenda:

Module 1: Basic concepts, endocrine and exocrine glands

Cholesterol biosynthesis

Biosynthesis of steroid hormones: Origin of Acetyl CoA, mevalonic acid,

Classification of steroid hormones: Glucocorticoids and gestagens, androgens, estrogens

Main biological activities of androgens and estrogens

Module 2: What is PCOS? What is SAHA syndrome?

What is PCOS? What is SAHA syndrome?

PCOS pathophysiology

PCOS Phenotypes

PCOS symptoms

PCOS Dx Criteria

Module 3: PCOS in adolescence

PCOS in menopause

Other causes of hyperandrogenism

Module 4: Interrelated alterations in PCOS

Neuroendocrine dysfunction

Metabolic dysfunction

Dysfunction of ovarian steroidogenesis and folliculogenesis

Module 5: Neuroendocrine Dysfunction (Details)

Metabolic dysfunction (Details)

Dysfunction of ovarian steroidogenesis and folliculogenesis (Details)

Module 6: Steroidogenesis and PCOS

Ovarian steroidogenesis

Follicles: Theca cells, granulosa cells and synthesis of steroid hormones

Biological activity of luteinizing hormone (LH) and follicle-stimulating hormone in follicles

Module 7: Source of androgens in adult women

Steroidogenesis and PCOS (CONTINUED)

Adrenal steroidogenesis: introduction. Adrenal cortex: glomerular zone, fascicular zone, reticular zone

Source of androgens in adult women and % production in different tissues

Module 8: Hypothalamic-pituitary-adrenal axis

Adrenal hyperandrogenism

Adrenocorticotropic hormone (ACTH) and its biological effects, impact on PCOS

Factors that influence bait production in G. Sebásea

factors that influence hair loss

Module 9: Lifestyle, supplementation, emerging therapies

Objectives of treatment/approach in PCOS

Nutritional strategies in the approach to PCOS and emerging therapies/approaches

Effects of training/exercise and modifications in carbohydrate intake in PCOS

Carbohydrates and calories in PCOS: Simple, complex, decrease in simple, general calorie deficit?

Rate of weight loss in PCOS for maintenance of muscle mass

Lifestyle, supplementation, emerging therapies

Melatonin and its benefits in PCOS: Improvement of female fertility and sleep

Module 10: Mechanism of action of combined oral contraceptives

Formulation of a combined oral contraceptive: Estrogen base, progestin base

Generations of combined oral contraceptives (1st, 2nd, 3rd, 4th)

Combined oral contraceptives, androgenic load and potential

Combined oral contraceptives contraindicated in PCOS due to their androgenic potential

Progestins: Derived from progesterone or derived from testosterone

Combined oral contraceptives: Impact, load and androgenic potential

Combined oral contraceptives: Impact at the metabolic level (insulin resistance)

Algorithm for the prescription and use of combined oral contraceptives in the management of women with PCOS

Combined oral contraceptives and nutrition in PCOS (vitamins and minerals affected)

Module 11: Insulin sensitizers and others

Biguanides,

Inositol and isomers, benefits of supplementation, effective doses

Insulin resistance or defects in post-insulin receptor cell signaling?

Berberine and benefits of its supplementation in PCOS and dosage of use

L-Carnitine, PCOS and female fertility

Module 12: Magnesium and PCOS: Functions, signs of deficiency, impact on metabolic health

Magnesium and pharmacogenic hypomagnesemia in PCOS

Causes of hypomagnesemia

Zinc and PCOS: Functions, signs of deficiency, benefits in PCOS

Vitamin D3 in PCOS: Functions, signs of deficiency, benefits of its supplementation in general health and PCOS and role of its deficiency in PCOS

Serum vitamin D3 concentrations in PCOS

Module 13: Statins

Selective cholesterol absorption inhibitors